Novel cationic cellulose beads for oral delivery of poorly water-soluble drugs

Cellulose beads emerge as carriers for poorly water-soluble drugs due to their eco-friendly raw materials and favorable porous structure. However, drug dissolution may be limited by their poor swelling ability and the presence of closed pores caused by shrinkage of the pristine cellulose beads. In this study, novel cellulose beads that can swell in acidic environment were prepared by introducing ethylenediamine (EDA) on dialdehyde cellulose (DAC), thereby addressing the shrinkage and closed pore problem of cellulose beads. The effect of the ratio of EDA on the swelling behavior and amine content of beads was studied. Three model drugs with different physicochemical properties were selected to study the physical state of loaded drugs and their release behavior. According to the results of XRPD and DSCindomethacin and itraconazoleloaded in the beads were amorphous at a drug loading of 20%, but fenofibrate was partially crystalline. Both bead size and the ratio of amine groups influenced the release behavior of the model drugs. The in vitro dissolution results showed that the cationic beads greatly improved the solubility and dissolution rate of the drug compared with the crystalline drug. Beads with a small size and high ratio of EDA tend to achieve a better drug dissolution rate and cumulative release percentage. Physical stability studies of the itraconazole-loaded beads were also implemented under four different temperature/humidity conditions for up to two months. The results showed that crystallization only appeared after two months of storage at 40°/75% RH, and the drug maintained a non-crystalline state in the other three storage conditions (0 °C/0 %RH, 0 °C/32 %RH, 25 °C/32 %RH). In conclusion, the novel pH-responsive cationic cellulose beads show great potential as a carrier for improving the rate and extent of dissolution of poorly soluble drugs and maintaining supersaturation.

International Journal of Pharmaceutics: X Volume 5, December 2023, 100146

13 Comments on “Novel cationic cellulose beads for oral delivery of poorly water-soluble drugs

  1. An impressive share! I’ve just forwarded this onto
    a co-worker who was conducting a little homework on this. And he actually ordered me lunch due
    to the fact that I stumbled upon it for him… lol. So let me
    reword this…. Thanks for the meal!! But yeah, thanx for spending the time to discuss this matter here on your blog.

  2. I blog frequently and I really appreciate your information. This article has truly peaked my interest.

    I am going to take a note of your website and keep checking for new information about once a
    week. I opted in for your RSS feed too.

  3. Can I just say what a comfort to discover someone who
    really knows what they are talking about over the internet.
    You certainly realize how to bring an issue to light and make it important.

    More and more people really need to read this and understand this side of the story.
    I can’t believe you aren’t more popular given that you certainly have the

  4. Hello are using WordPress for your blog platform? I’m new to the blog world
    but I’m trying to get started and create my own. Do you require any html
    coding knowledge to make your own blog? Any help would be greatly appreciated!

  5. magnificent publish, very informative. I wonder why the other
    experts of this sector do not understand this. You should continue your writing.
    I’m sure, you have a great readers’ base already!

  6. Hello, I think your blog might be having browser compatibility
    issues. When I look at your blog site in Firefox, it looks fine but when opening in Internet Explorer, it has some overlapping.
    I just wanted to give you a quick heads up! Other then that, great

  7. It is perfect time to make a few plans for the longer term
    and it is time to be happy. I’ve learn this submit and if I
    may I want to recommend you few fascinating issues or advice.
    Maybe you could write subsequent articles relating to this
    article. I wish to read even more issues about it!

  8. My coder is trying to persuade me to move to .net from
    PHP. I have always disliked the idea because of the expenses.
    But he’s tryiong none the less. I’ve been using Movable-type on numerous websites for about a year and am anxious
    about switching to another platform. I have heard excellent
    things about Is there a way I can import all my
    wordpress posts into it? Any kind of help would be greatly appreciated!

  9. Write more, thats all I have to say. Literally, it seems as though you relied on the video to make your point.
    You obviously know what youre talking about, why waste your intelligence on just posting videos to your weblog when you
    could be giving us something enlightening to read?

  10. Howdy! Someone in my Myspace group shared
    this website with us so I came to give it a look.
    I’m definitely enjoying the information. I’m book-marking and will be tweeting this to my followers!
    Fantastic blog and fantastic design and style.

  11. Does your blog have a contact page? I’m having problems locating it but, I’d like to send you
    an e-mail. I’ve got some suggestions for your blog you might be interested in hearing.
    Either way, great website and I look forward to
    seeing it develop over time.

Leave a Reply

Your email address will not be published. Required fields are marked *