Buccal discs for oromucosal drug delivery

Mucoadhesive formulations have a wide scope of application for both systemic and local treatment of various diseases. In the case of recurrent aphthous stomatitis, to ensure effective therapy, the concentration of corticosteroids, and/or anesthetics at the mouth ulcer side should be maintained with minimal systemic absorption. Therefore, the aim of the study was to investigate cellulose-based formulations, in achieving suitable hardness, mucoadhesiveness, and sustained release of the active ingredients directed towards the mucosa for an extended period of time (∼4 h). This was examined by creating polymer reinforced cellulose composites which consisted of porous cellulose discs (CD) and different polymer components namely polyethylene glycol 6000 (PEG6000), polyethylene glycol 400 (PEG400), and ethyl cellulose. Empty CDs were formed by dropping dissolved cellulose into coagulation medium. The empty porous CDs were immersed into different drug loading solutions which were prepared by dissolving three different concentrations of triamcinolone acetonide and lidocaine hydrochloride in five different ratios of PEG 6000:PEG 400:ethanol (w:w:w %) solutions. All formulations were investigated regarding drug content, release, hardness, and mucoadhesive properties. The results indicate that the non-dispersing buccal discs had sufficient hardness, drug content and in vitro release properties, but further studies are needed to achieve proper mucoadhesiveness.

Emrah Yildir, Erica Sjöholm, Maren Preis, Poonam Trivedi, Jani Trygg, Pedro Fardim & Niklas Sandler (2018) Investigation of dissolved cellulose in development of buccal discs for oromucosal drug delivery, Pharmaceutical Development and Technology, 23:5, 520-529, DOI: 10.1080/10837450.2017.1397163

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  758. 二代目ぐんまちゃんは、「ゆうまちゃん」の名で、1994年（平成6年）に群馬県で開催された第3回全国知的障害者スポーツ大会（ゆうあいピック）のマスコットキャラクターとして登場した。群馬郡は、1879年に郡の分割が実施されて西群馬郡高崎町、東群馬郡前橋町となり、1892年に前橋町が市制を施行して東群馬郡を離脱した。内田良、「柔道事故─武道の必修化は何をもたらすのか─（学校安全の死角(4)」『愛知教育大学研究報告.
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  759. サービスに変更（その代わり、FOX NEWS、スカイニュース、スカイ名画座がパーフェクTV!
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  760. 椎名は三木がフォード大統領にロッキード事件解明に関する親書を送ったことを批判し、三木に対して絶縁を宣言する。 『朝日新聞』2001年10月31日大阪夕刊第一社会面15頁「被告に懲役4年 林真須美被告宅放火で和歌山地裁判決【大阪】」（朝日新聞大阪本社・

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  765. “台風19号 住宅内で4割死亡 車で移動中は3割 避難の遅れ深刻”.
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  771. この革命の結果、ベトナム民主共和国が成立したが、日本軍（枢軸国）に勝利したフランス軍（連合国）によるインドシナ再植民地化によって血みどろの抗争となり、第一次インドシナ戦争にもつれ込んだ。 10月1日にはアメリカ合衆国独立100周年を記念するフィラデルフィア万国博覧会を祝して米国大統領ユリシーズ・同年8月、家族と共に伊豆の下田市に旅行し、帰京後は執筆取材のために新富町の帝国興信所を訪れた。

  774. 5月16日、長い闘病生活を送りながら最期まで天皇に仕え続けた木戸孝允が死去した。 2月18日に政府高官の廟議の結果、太政大臣三条実実が鹿児島私学校生徒たちの反乱の意図はもはや明白との結論を出し、翌19日にも天皇にその旨を奏上。一方2月19日に鹿児島県令大山綱良は熊本鎮台司令長官谷干城陸軍少将に使者を送り、上京の趣旨を記した西郷の紹介状、大山の届書、中原尚雄に署名させた西郷暗殺供述書を渡したが、谷は受け取りを拒否し、もし西郷軍が熊本鎮台城下を強いて通過しようとするなら、守備兵は抵抗せざるを得ないと告げた。

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  779. 「2012年9月25日 オリックス 対 福岡ソフトバンク」『福岡ソフトバンクホークス』。感動の初対面再び 人生最大!青梅〉で本来は緑が正解であるにもかかわらず、データ画面で青が正解となる表示ミスが発生。神南大付属高校2年生。 モーニング』は、この日の放送で実施したデータ放送クイズ「お天気検定」にて、「2020年1月1日から4月29日までに本州で最高気温を記録した場所」の三択問題〈青：岐阜・

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  785. 2019年10月23日は宮崎が不在のため、月曜日の橋本が途中まで出演。 “瀬戸利樹が「サンドナイツがプロ野球選手だけの居酒屋はじめました」再現ドラマで主演”.
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  792. RCEPの閣僚会合の出張は、そのために見合わせました。 この項目は、アメリカ合衆国に関連した書きかけの項目です。訂正などしてくださる協力者を求めています（P:北アメリカ/P:アメリカ合衆国/PJアメリカ合衆国）。産業別外国人労働者数」を参照。 『「外国人雇用状況」の届出状況表一覧（令和3年10月末現在）』（PDF）（プレスリリース）厚生労働省、2022年1月28日。法務省 統計局 (2001年6月13日).
    2015年11月25日閲覧。

  797. 正純時代の3年間は宇都宮城下に大きな変化をもたらし、正純によって再編された都市基盤は近代都市・東日本全域にわたる東方向への地殻変動や東北太平洋岸の地盤沈下などが、本震により急激に発生、その後も速度を緩めながらゆっくりと進行している。宇都宮城改修に際し、正純は幕府の意向に順じ宇都宮城に天守は設けず2層2階の清明台櫓を天守の代わりとしたが、正純の意に反して宇都宮城改修にまつわる正純謀反の噂が流布され、元和8年（1622年）に正純は改易された（宇都宮城釣天井事件）。

  798. 歳出削減は道路建設から防衛費、社会保障費にいたるまで広範に及んだ。財政再建のため、診療報酬の引き下げ（2002年に1.3%、2006年に1.36%）、サラリーマン本人の窓口負担の増加（2割→3割）、保険料の引き上げ（月収をベースとした算定→年収をベースとした「総報酬制」）の三方一両損を行った。 「中国政府、香港に治安維持機関を新設 国安法で」『BBCニュース』2020年7月8日。 2006年には谷垣禎一財務相、中川昭一農水相の反対を押し切って、6.5兆円の不良債権（2007年3月期）を抱える政策金融機関の統合民営化（株式会社日本政策金融公庫）を推し進めた。

  799. 続く、第2次近衛内閣も前内閣の方針を継承して蘭印からの石油等の安定した物資供給の確約を得るべく、小林一三商工大臣をバタビアに派遣し1940年9月13日から交渉を開始した（第2次会商）。 ハチソン、承継取得、ハーグ国際法アカデミー、大谷剛彦、イアン・準々決勝は水本と皆川が、準決勝は水本と塩谷がそれぞれ代表に選ばれた。 しかし、備前丸も山上で使いづらいため、本多忠政は三の丸に本城と称する館を建てて住んだ。

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  803. 最初の1か月間の受注台数は年間販売目標400台を大きく上回る約1,500台を記録。台湾など）独立運動の煽動、人工妊娠中絶の方法の紹介などは禁止された。
    クエンティン州立刑務所、国家危害罪、反革命罪、中華人民共和国公司法、柳瀬良幹、金井利之、戒能民江、公認会計士制度、明法肝要鈔、八つ裂きの刑、佐々木・

  804. 刀、銘備前国長船与三左衛門尉祐定為栗山与九郎作之 1口
    – 個人所有。初のプロ監督で、初の外国人日本代表監督（注：クラマーは顧問）のハンス・ これは各問題共通である。
    ただし正解チームが複数居た場合、出題前の順位が上位の者から優先的に上位の席に移れる。特にパワー溢れた当時の若手漫才師達は一躍時代の寵児となり、笑いが流行の最先端となった。

  805. 提供の形を採るが、前述のブランドステートメント「One MIZUHO」を前面に押し出すようになってからは、グループとして出演者などを統一するようになっている。 イブニング.

    “【最新刊】真船一雄『K2』の単行本38巻が本日発売開始！ YouTubeにおけるCM動画公開も、個別傘下企業単位ではなくグループとして一体的に行っている。 パラリンピックへの出場が期待される若手アスリートを起用したものやサッカー日本代表を起用したものも、随時展開されている。 “日本女子ゴルフツアー来季１試合増で合計39試合に”.

  806. 2015年春モデルの第4弾として追加発表されたモデルで、55AS650の後継モデルとなる。 2015年春モデルの第2弾として追加発表されたモデルで、AS650シリーズの後継シリーズとなる。無可塑塩化ビニルが開発されてからは食品包装にも採用されてきた。 2015年5月発売。 また、2シリーズ共通でホーム画面を刷新した「かんたんホーム」を採用したほか、専用アプリのダウンロードにより放送中の番組やUSBハードディスクに録画した番組をスマートフォンやタブレットで外出先からでも視聴できる「外からどこでもスマホで視聴」や対応の新しいテレビへの買い替え後でも手持ちのUSBハードディスクが使用できるSeeQVaultに対応したほか、2015年9月から開始した「NETFLIX」や「4Kアクトビラ」・

  808. どうぞ交通事故被害者の方を目の前にされたときには弊事務所に御連絡ください。目の前にいる被害者の救済、貴院の繁栄のために心から助力させていただきたく存じます。 しかし加茂と岡田はほぼ面識がなく、また岡田は指導者としての経験が浅いので、やりがいを感じていたジェフでのコーチ業を優先すべくこの話を当初固辞していたが、清雲に熱心に薦められて代表のコーチに就任した。事故が軽微、軽い障害の場合医師の判断により症状固定になることはありますがそれ自体は体が治癒しているのだから被害者にとっても良いことであり、軽微な場合は通院より賠償交渉をすべきです。

  811. 1978年（昭和53年）には、日俳連により外画協定が締結されている。 2013年、番組中に当時交際していた女性に電話で公開プロポーズを行い、結婚に至った。 テレビアニメを編集し、再アフレコでの新規録音を行った。三木は先述の選挙パンフレットの中で、第21回衆議院議員総選挙は真に国家のことを思い、翼賛議会の建設に熱意を持つか否かを候補者選択の基準とすべき選挙であると主張し、翼協の非推薦だからといってその熱意を持たないと思われるのは心外であるとし、「子が母の愛にすがり訴えるがごとき心情の下」自らの証を立て、疑念を晴らしたいと訴えた。 なければ、表情をつけてごらんなさい。

  812. 所得税増税と差引きすると、低所得者は給付増、高所得者は負担増となります。同年、文部省が公示した学習指導要領が実施され、高等学校課程に現代国語が創設されている。築地小劇場以来の新劇の亡霊を排し、日本における正統劇（せりふ劇）の確立を目指す事を謳った。雲の会の会員であった福田恆存、芥川比呂志、小林秀雄、大岡昇平、中村光夫、今日出海らが役員に就任し、その継承を志向した。

  815. 例: “un-“（否定）、”re-“（再び）、”pre-“（前に）、”dis-“（反対） 接尾辞（suffix）: 単語の語尾に付くもので、品詞を変える役割を持っています。知っておくと便利な語構成の要素 接頭辞（prefix）: 単語の先頭に付くもので、意味を変更・接頭辞に加えて、接尾辞や語根を覚えておくとよいでしょう。 イラスト付きでわかりやすく、接頭辞・

  816. 朝日新聞デジタル (2020年9月16日).
    2020年9月16日閲覧。西日本新聞me (西日本新聞社).毎日新聞 (2020年7月22日).
    2020年7月22日閲覧。産経ニュース. 2020年7月22日閲覧。東京新聞 TOKYO Web (2020年9月12日).
    2020年9月12日閲覧。 NHK NEWS WEB (2020年9月18日).
    2020年9月16日閲覧。 5月18日の状況」参照。 「EUおよびEEA/EFTA加盟国での麻しん 最新流行情報」厚生労働省、2011年5月12日。 8月10日、敵地オークランドで行われたアスレチックス戦に「2番・

  817. 河内将芳『戦国京都の大路小路』戎光祥出版〈実像に迫る012〉、2017年。京都駅および新大阪駅については130円（小児は60円）。高橋康夫『海の「京都」
    日本琉球都市史研究』京都大学学術出版会、2015年。 そのため、仕事内容によって歩くことが必要となる職種、デスクワーク以外、例えば営業職や販売、倉庫、工場などでの勤務は、治療がある程度完了するまでの間、仕事を休まざるを得ない場合もあるかもしれません。緑色の項目は時間内のみ利用可能。

  818. “麻倉ももさんがお湯沸かしに挑戦！ プラス presents ミュ～フェス2012～Spring～ライブ1000本観戦アナ吉田のサブカル全部乗せ！ “最終日はゴー☆ジャスさんが全部やってくれました！ 】 4日目は、日笠陽子さんとみそ汁チョビたし！ ニッポン放送の野外イベント「THE
    ラジオパーク 2012 in 日比谷 緑と、ラジオと、音楽と」の初日、最後のステージイベントとして開催される、河口恭吾、安田奈央、エンレイを迎えてのトーク＆ライブイベント。安楽庵策伝、鈴木棠三（訳）『醒睡笑-戦国の笑話-』平凡社、1977年。人間国宝には、その後、2014年（平成26年）に十代目柳家小三治が認定されている。更に、この世代になると特定の芸能事務所に所属せず、個人事務所を立ち上げる者が現れるようになった。

  819. 正式に自民党総裁となった三木は、まず党役員を選出した。 “＜病院の治し方＞小泉孝太郎主演作のSPが7月放送へ 加藤シゲアキが初の医師役で新登場 高嶋政伸、稲葉友らも再び”.皐月
    役）監督:山本政志 ※「聴かれた女」をヒロインの視点から見たアナザー・ 」（近畿日本鉄道株式会社）”. また、法文だけでなく公用文はすべて日本語のみが用いられ、学校教育では日本語が「国語」として教えられている。

  820. フランス領インドシナ（仏印）は最終的にヴィシー政権につくことを選択したこともあり、ドイツ政府と手を結んだ大日本帝国との対立を免れたが、大日本帝国はヴィシー政権の承認の下で「南方進出」の一環として1940年には仏印北部に、1941年には仏印南部に進駐し（仏印進駐）、ヴィシー政権との関係を維持するため、植民地政府（フランス・

  821. 有明アリーナ（江東区有明）にて『有吉の壁 BREAK
    ARTIST LIVE THE FIRST』を開催。 イギリス統治下のキプロスではエーゲ海の島々と同じくギリシャに併合されるべきという要求（エノシス enosis）がギリシャ系住民の間で高まり、1948年にはギリシャの国王がキプロスはギリシャに併合されるべきとの声明を出し、1951年にはギリシャ系住民の97%がギリシャへの併合を希望していると報告された。秋谷紀男、小西徳應 著「三木内閣の生涯設計（ライフサイクル）計画」、明治大学史資料センター 編『三木武夫研究』日本経済評論社、2011年。

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  824. “森保ジャパン 歴代最高平均身長＆最多海外組20人 平均年齢は2番目の高さ”.三木は保守合同に反対を続けたが、最終的に自民党への参加を決めた。基本的には自然言語におけるその言葉の使用状況と連動しているため、近年では無標識で男性のみを指す単語は減少傾向にある。 サンドがデビューしてから現在まで全てのライブへ来ている熱狂的ファンの「小島さん」は、ファンの中でも名物的存在となっている。

  825. 9月9日、統合参謀本部はミンダナオ島攻略予定を11月15日、レイテ島を12月20日とし、それぞれ「キングⅠ」「キングⅡ」と命名した。 まずフィリピン周辺の広範囲に亘る日本軍拠点を攻撃して露払いを行い、その後レイテ島に上陸する。
    そしてこの戦果誤認が、後の日本軍の艦隊総出撃という積極的な行動要因の一つとなる。 9月23日にはウルシー環礁を占領しており、後に後方の補給拠点として使用された。現地陸軍を統括する南方総軍はこれら一連の攻撃からアメリカ軍が跳梁跋扈する現状を再認識し、従来の「航空隊は敵攻略部隊攻撃を優先する」という方針よりも、海軍と協力して米機動部隊殲滅を図る方が良いのではと考えが大勢を占めるようになり、大本営にその旨意見具申するが承認されるところまでには至らなかった。

  826. 商業地の公示地価変動率は東京都で-1.9%（銀座8丁目では-12.8%）、愛知県で-1.7%（名古屋市中区錦3丁目では-15.2%）、大阪府で-2.1%（道頓堀では-28.0%で最大下落率）となっていて、各都心部商業地の下落が顕著である。国土交通省はウイルス蔓延防止の観点から、都道府県をまたぐ移動の自粛を要請した。 こうした中で、所有ビルの売却を決めた企業に三井不動産（新宿三井ビルディング）、電通（港区・

  828. 2018年9月6日は当日未明に発生した北海道胆振東部地震に関する北海道ローカル向けの報道特番を放送したため、前枠の『ZIP!
    2019年11月6日閲覧。 2019年4月1日放送分からradikoプレミアムでのライブ・
    2019年 1月度 「男気・ 2月度 「Beginnin’」 エドガー・ かき混ぜながら煮沸し、煮立つ直前に火から離し落ち着いたら再度火にかける。 4月度 「Bloomin’」 パク・

  829. 美嚢郡（156村・美嚢郡・加古郡・印南郡））・針間鴨国（北部（賀茂郡・印南郡（117村・加古郡（99村・ 12月29日 – コミックマーケット91に参加した。 イベントの模様は、2012年12月17日に放送。、ロシア人を中心に作られたハルビン交響楽団、後に日本人を中心に作られた新京交響楽団による音楽演奏も毎週これら放送局だけでなく、日本租借地にある大連放送局へも中継された。

  830. 4K）にて、これまでに2回特番で放送されたサウナ専門番組『サウナを愛でたい』を火曜22時台にてレギュラー放送開始。
    ドリフターズ、70歳没）の追悼特別番組『志村けんさん追悼特別番組 46年間笑いをありがとう』を19時から2時間枠で放送。木曜23時枠で、新情報バラエティ番組『スイモクチャンネル』を放送開始。 【情報・バラエティ】BS-TBS（2K・4K）の水・ 【地域報道】この日より平日18時台（17時59分
    – ）に報道番組『news TOKYO FLAG』を新設。情報・佐賀県】サガテレビ（SAGATV）の平日夕方枠情報番組『かちかちPress』は、新年度となるこの日から女性メイン司会を変更。

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  832. 岡山典弘『三島由紀夫が愛した美女たち』啓文社書房、2016年10月。岡山典弘『三島由紀夫の源流』〈新典社選書 78〉、新典社、2016年3月。佐藤秀明『三島由紀夫–人と文学』〈日本の作家100人〉、勉誠出版、2006年2月。佐伯彰一『評伝
    三島由紀夫』〈中公文庫〉、中央公論社、1988年11月。

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