TEMPO-oxidized cellulose beads as potential pH-responsive carriers for site-specific drug delivery in the gastrointestinal tract

The development of controlled drug delivery systems based on bio-renewable materials is an emerging strategy. In this work, a controlled drug delivery system based on mesoporous oxidized cellulose beads (OCBs) was successfully developed by a facile and green method. The introduction of the carboxyl groups mediated by the TEMPO(2,2,6,6-tetramethylpiperidine-1-oxyradical)/NaClO/NaClO2 system presents the pH-responsive ability to cellulose beads, which can retain the drug in beads at pH = 1.2 and release at pH = 7.0. The release rate can be controlled by simply adjusting the degree of oxidation to achieve drug release at different locations and periods. A higher degree of oxidation corresponds to a faster release rate, which is attributed to a higher degree of re-swelling and higher hydrophilicity of OCBs. The zero-order release kinetics of the model drugs from the OCBs suggested a constant drug release rate, which is conducive to maintaining blood drug concentration, reducing side effects and administration frequency. At the same time, the effects of different model drugs and different drug-loading solvents on the release behavior and the physical state of the drugs loaded in the beads were studied. In summary, the pH-responsive oxidized cellulose beads with good biocompatibility, low cost, and adjustable release rate have shown great potential in the field of controlled drug release.

Molecules 2021, 26(4), 1030; https://doi.org/10.3390/molecules26041030

Keywords: TEMPO oxidation; cellulose beads; pH-responsive; controlled drug delivery systems; zero-order release; indomethacin; fenofibrate

75 Comments on “TEMPO-oxidized cellulose beads as potential pH-responsive carriers for site-specific drug delivery in the gastrointestinal tract”

  32. **glpro**

    glpro is a natural dietary supplement designed to promote balanced blood sugar levels and curb sugar cravings.

  33. **sugarmute**

    sugarmute is a science-guided nutritional supplement created to help maintain balanced blood sugar while supporting steady energy and mental clarity.

  34. **vittaburn**

    vittaburn is a liquid dietary supplement formulated to support healthy weight reduction by increasing metabolic rate, reducing hunger, and promoting fat loss.

  36. **glucore**

    glucore is a nutritional supplement that is given to patients daily to assist in maintaining healthy blood sugar and metabolic rates.

  41. **mitolyn**

    mitolyn a nature-inspired supplement crafted to elevate metabolic activity and support sustainable weight management.

  43. **yusleep**

    yusleep is a gentle, nano-enhanced nightly blend designed to help you drift off quickly, stay asleep longer, and wake feeling clear.

  48. **pineal xt**

    pinealxt is a revolutionary supplement that promotes proper pineal gland function and energy levels to support healthy body function.

  59. **cellufend**

    cellufend is a natural supplement developed to support balanced blood sugar levels through a blend of botanical extracts and essential nutrients.

  61. **revitag**

    revitag is a daily skin-support formula created to promote a healthy complexion and visibly diminish the appearance of skin tags.

  74. fantastic post, very informative. I wonder why the opposite specialists
    of this sector don’t understand this. You must continue
    your writing. I am confident, you have a great readers’ base already!

  75. certainly like your website however you need to check the spelling on quite a
    few of your posts. Many of them are rife with spelling problems and I to find it very
    bothersome to inform the reality on the other hand I will surely come again again.

Leave a Reply

Your email address will not be published. Required fields are marked *